Neonicotinoids are presented as unreplaceable insecticides in modern agriculture as the only alternative is pyrethroid for which farmers face more and more resistance.

Like for any pesticide, their use induces the emergence of insect resistance as was recently confirmed...

http://www.weeklytimesnow.com.au/agribusiness/cropping/green-peach-aphid-new-chemical-resistance-discovered/news-story/ee44329d02366caf3abd6c0c859f823e